2000 S10 pickup just wines but want crank let it set 2or 3 weeks then it will crank

S10 wiring.

2000 Chevrolet S10 Pickup Stereo Wiring Chart

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Our 2000 Chevrolet S10 Pickup radio wiring guide shows you how to connect car radio wires and helps you when your car radio wires not working. It also shows you ...

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start with is it a fuel delivery problem or no spark and go from there

on a v engine with a single cam
the timing marks face each other
crank up and cam down

No Start No Spark Cranks OK GMC Jimmy S10 Blazer

It sounds like a electrical problem with the rotor and cap, replace the cap and rotor. How To Install Replace Cap and Rotor Chevy GMC S10 Blazer Jimmy Pickup...

you mean,cranks ok, but will not start and no fuel , right>?
s10 no fuel. 1988 ( S10 blazer )
please do say , what that means.
1: car cranks and will not start. so must be out of fuel?
(over 50 causes, or better is 10 or less tests (ask)
2: same, and fuel pressure is 0 psi (spec.9-13). gauged.?
3: fuel dribble test?
4: sparks good so tired test fuel and it ran on test fuel ok? proving
loss of fueling>?
5: injector dead cranking, (eyeballs)

which was it?

1988 cars in the USA are BIG TIME TRANSITION year.
we went from CARBS to EFI.
2.5L (what is E)?
gear cam, roller HLA lifters.
your car, USA , is TBI engine,
TBI started on THIS car in 1985 (1/2 and 1/2)
Throttle body injection
an on all TBI engines, one can see it inject with eyes.
does it?
if not it can be the following things.
1: no fuel pressure, 9-13pis.
2: ECU is cutting fuel. Pressure good cranking.
2a: ECU is sending error for bad crank/cam sensors, and cuts fuel.
2b: ECU sees rpm or tacho line dead.
2c. ECU sees TPS sensor output as 4v or more cranking, this cuts all fuel.
3: if ECU is happy, it sends 12vcd to the pump, cranking.
all tests must be dont cranking or chase tail.

IF YOU RECENTLY UNHOOKED BATTERY OR HAD DEAD BATTERY THE COMPUTER WILL NEED TO RELEARN IDLE STRATEGY,START VEHICLE KEEP IT RUNNING AND DRIVES ON 2OR 3 MILE RUN SHOULD BE SUFFICIENT IF THIS DOESN,T WORK LOOK FOR VACUUM LEAKS IN ENGINE COMPARTMENT OR POSSIBLE BAD IDLE AIR CONTROL LOCATED NEAR THROTTLE BODY

I'd use a gage and check proper fuel pressure, key on engine off, 60--66 psi with spider fuel system.
Engine cranking did you visually check for spark at the spark plugs? Engine cranking is there a fuel injector pulse?https://s8.postimg.org/50arofh11/fuel_pump.jpg
Click on the link for fuel pump relay, you can check the fuse. At the fuel pump, gray wire is voltage, black is ground.

take a piece of that line to the auto parts store and they can matrch is up and cut it to the desired lenght

i would check your ignition system. you would need a meter for this but look for broke or loose connections. if it was a fuel problem i dont think it would just start up after 20 minutes. or you might try your ignition switch. if its shorting or something then ya well it would cut your engine off real quick