2000 s10 Blazer dies very 3-6 weeks for no reason

I saw what you replaced, didn't see any testing? What testing have you done? Make sure battery has a full charge?
When the problem is ongoing, have a helper crank it, while you check for spark at the plugs. If spark everywhere, use a gage and check proper fuel pressure. Also, check fuel injector pulse. Any applicable trouble codes?
If you have the spider fuel system, that system is noted for problems.

You may be having an intermittent failure with the fuel pressure regulator - checking the fuel pressure when the truck won't start may pinpoint this problem. If the pressure looks OK, this same problem can be caused by the ignition system as well (ignition coil or control module).

I have 94 s 10..4.3 v6. it does the same thing have replaced fuel pump and filter,ignition module,cap rotor plugs wires,coil,ground strap...driving down the road jus dies like the key got shut off....for a while when troubleshooting through the parts you could get it to restart.....now when it dies it cranks really hard when trying to restart..ive checked the timeing its fine....if i wait a few min it will usually start...sometimes it will show a check engine light sometimes not......never know when it will happen sometimes jus down the the road from the house sometimes 100miles down the road......sometimes three times in a mile sometimes not for weeks at a time..Wtf...Im ready to shoot it like a lame horse....its a shame too its a sharp lil truck thats a two owner and never spent a night outside in its life...i knew the original owner ...i bought it with 90,000 on it it only has 148,000 now and still looks like new...

Try the fuel pump relay or try another fuel pump.

only half way there if you have a tbi check the crank sensor/ cam sensor that is the first line of business on that truck if the crankshaft sensor fails the truck stops dead when you wait a few minutes the sensor re energizes and the truck will work again for a bit antiknock can cause similer problems but not while the truck is running

sounds like the new fuel pump sucked dirty gas out of the tank try changing the fuel filter and put some fuel injector cleaner in the tank, also check the fuel line it may be bent from changing the fuel pump

try checking the fuel injection module out, ( "spider injection module"). My 2000 blazer did the same thing, fouled out the plugs and all, i hooked the fuel pressure gauge up and had good fuel pressure, just no start. I took it to the shop and they found the injection module to be the culprit. you'll need to replace the plugs if it was the problem since you cranked and cranked it over.

Just having fuel is not enough on this engine, here are the spec's. Even 1 psi out of spec can cause a no start.

Fuel Pressure
Pressure 1 (PSI) Pressure 2 (PSI) Pressure 3 (PSI) Range Note Range Note Range Note 60.0 - 66.0 Y131 50.0 - 63.0 Y132 66.0 Y133 Y131: System pressure with ignition on (PSI).
Y132: System pressure while idling (PSI).
Y133: Fuel pump pressure (PSI) with return line briefly restricted.

it may work again but that is only temporary it sounds like the fuel filter is clogging up

Make sure that your fuel presure is up to at least 60 psi if not that could be your problem. If not, make sure you are getting spark, if not could be your Crank sensor or ingniton module ECM. Usually if your Engine control module wouldn't be bad because of your fuel pump is working, but may not be putting out the proper pressure for the fuel system. Fuel Pumps are a Problem with that year..