I would suggest removing the rear seat and then you may be able to pinpoint the noise easier, even though the noise may appear to come from the interior it may be outside and the noise transfered through various body mountings , these type of things can be very time consuming to locate and patience and logical thinking will get you to the answer. this link might provide you with some help
Rattle Noise Inside Panel Rear Hatch Door 10 RX 350 Club Lexus Forums
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