DO NOT USE a guitar pedal in effects loop as it has the WRONG signal levels.
Also, when you boost the gain preceeding a distortion setting in an amp, the amp will just limit out and it will appear that the effects in the amp aren't working... but what is happening is you wind up with too much input signal and the "flat topping" distortion occurs right at the inout of the amp so no further can occur when you select a distortion in the amp.
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