My engine fuse keeps blowing in fuse compartment drivers footwell on 04 Kia Sedona it has two wires coming out of it do you know what these wires operate

https://fusesdiagram.com/kia/fuses-and-relay-kia-sedona-1999-2006.html
04 Sedona fuse box diagram
https://www.autogenius.info/kia-sedona-2002-fuse-box-diagram/

https://www.autozone.com/repairguides/Kia-Sedona-2002-2006/Wiring-Diagrams/Wiring-Diagrams-3-of-4/_/P-0996b43f803760e2

check the wiring near the trailer hitch for breaks shorts and places where the wires enter/leave any metal channels where the wires arent in a plastic cover(available at parts stores)sometimes the installers will not cover the wires and they get pinched or wear through causing a short..once repaired, put the wire in a protective cover and tape the ends so it wont move..repost with findings please...

Not 100% on the first part of the question...but fuses blowing makes me think faulty wiring is to blame. Check for frayed or damaged wires.

There are 2 sets of fuses. Another one is by battery under hood. Yes two fuse boxes.

My kia sedona minivan keeps blowing the fuse to the a/c compressor. Does this mean that I have a bad compressor or is there a less expensive esier fix? Any ideas?

The fusable link wire to AC compressor may be shorting it out.

When was last time plugs & wires checked or replaced, as well as fuel filter.

Either AC compressor or AC clutch failure or both highly likely as Kia Sedona has notable history of this

Sure, one might trace the wire that connects to the compressor, and while its challenging to reach without removal of both fans, it does follow upward into the engine wiring harness. At that point its much more convenient to push a needle into the wire and connect a meter to it to see if it is energized when AC selector on, cabin fan on and cabin thermostat set to coldest setting.

If no voltage then check fuses and try swapping idential relays in the engine compartment box to be sure. If voltage present, then assume the worst.

More important is why the failure. I'm convinced a design error by Kia relative to the suction or low pressure hose is the root cause of such frequent AC compressor or AC clutch failures. You can buy a new Kia OEM suction hose, position it for to install and observe immediate kinking and or collapse. Kia has likely long been aware of this problem but never conducted a recall. You can solve it permanently, toss your existing suction hose and buy this one: http://cgi.ebay.com/ebaymotors/ws/eBayISAPI.dll?ViewItem&item=181880844799

If you buy a "Tough One" brand replacement compressor and filter/dryer together from Advance Auto Parts it has a lifetime replacement warranty. No other compressor is sold with a lifetime warant for a Kia Sedona, not even from Kia itself.

REMOVAL OF THE PLUGS:

Do not attempt any maintenance on spark plug if engine is hot. 
1. Disconnect negative battery terminal. 
2. Carefully remove high-tension leads. 
3. Use compressed air to blow any dirt or debris from around spark plug hole. 
4. Check that spark plug fits squarely in spark plug socket and remove spark plug.

Raise a vehicle and install SST(OK552 131 001) in order to replace cylinder 2, 4, 6 spark plug. 

INSTALLATION:

1. Install spark plug into cylinder head.

Tightening torque : 18~22lb-ft (25~30N·m, 2.5~3.0kg-m)

2. Reconnect high-tension leads. 
3. Reconnect negative battery cable. 

Hope this helps and simple to understand. Good luck