I have a large spot on the right side of the LCD screen, it looks like a large water spot does it mean the VIZIO TV is going out? What can I do to make it disappear.

The Vizio "E" (economy) series sets have local diming, on most brands if some of the lamps go bad the screen is black but not on these model Vizio TV's, for this reason it's harder to troubleshoot the set for possible bad backlights or backlight inverter issues. If you have a LED backlight tester you can test each zone at the backlight connector off the inverter board to see if each is working, without a tester you're going to need to remove the panel then move strips that don't light to ones that do and see if it's the strips bad or inverter issues.

If you wish to get some details; visit the site linked here. Pull up older posts.
https://electronicshelponline.blogspot.com/
Line faults & possible causes to LCD & Plasma screen are given with illustrations./

Hi Brandon,
I am afraid that the dark spot in the screen is not repairable. Manage as long as you can or go for a new tv.

Not a good idea to clean tv with windex. Try wet towel dipped in mild soap solution. Make sure all water has been removed and towel is only wet. When tv off, try removing the spots. Turn tv on only after tv dry.

The cost of the screen, and the tools needed to make it work with your current TV would be more expensive than it would be buying another TV. Go find the gamer that caused the damage and get them to buy you a new TV.

A large black spot usually means the LCD screen is damaged. It may have fine cracks around the black spot. In this case the LCD screen needs to be replaced.
A replacement screen maybe available for your laptop from this WEB site.
LCD screens and Inverters www.lcdparts.net

HI...
It's probably a loose flex cable inside. Look on the web and find someone near you

Have a service tech check it inside for you

In most of the case, the problem is a defective display LCD panel, this problem in some terminology is called PIXEL RETAINING, it means the pixels are locked up, there is no good permanent solutions for it, you have to change the LCD panel.

A single line out means a bad LCD panel..The cost for parts will exceed the cost of replacing the TV...

The dots cannot be rectified, static dots of this kind on an LCD panel are dead pixels or liquid cristal leaks, depending on their hape and aspect.

The only fix is by replacing the LCD panel, that is an expensive part and must be ordered by phone, as it is not normally in stock.

You can inquire by phone here to find out part price.