I just baked one loaf, and was readying the 2nd loaf, entered settings, hit start and got this: "E:01" What do I do?

That is a temperature warning that is an automatic feature on bread machines. What the machine is telling you is that the oven chamber is still too hot from baking the last loaf. It does that to prevent you from starting another loaf and having that loaf fail due to the high heat killing the yeast. If you want to bake more than one loaf unplug the machine after baking the first one, raise the lid, and leave it open for no less than 20 minutes. It should work fine by then. If not let it cool off another 10 minutes. It will be cool enough by ½ an hour to start another one.