I have a 42" Visio

That sounds like a faulty LCD panel tab. The only true fix is to replace the screen. This usually isn't cost effective.

If totally dead it appears to be a power supply issue.

By manual I guess you mean the buttons on the TV and not switching the actual cables. my recommendation is to get a good new universal remote. My personal preference for my Vizio TV is the Logitech 650. Just know that you program it on a computer. It controls up to 6 devices (TV, DVD, Cable box, audio and more), is easy to program with no codes to enter. I am sure it is easier to get then a new Vizio remote though a little pricey at $60.
Hope this helps,
Cullen

it sounds like you need to purchase a new video board from vizio which is expensive. upwards of 600 dollars. walmart has vizio 42 in and 47 in 1080p models around 500 dollars on sale this weekend. hope this helps let me know!

The easiest thing to check for is the mute button isn't activated. IF that isn't it, you might want to go thru the on screen menus and check under the audio tab. Make sure it is selected to "on" in menu. Let me know what you fine...Good luck Sincerely HDTV GURU JAY

I have the same TV with the same problem. I'm getting tired of hitting it.

I have been told more than once that if you usa a "Visio" LCD TV in a hot area, such as near a window that gets a lot of sun, they will ****-out. Very sensitive to heat is what I have been told.

I would like to know what to do other than chucking the POS in the trash and buying a new LG.

you need to buy another screen or you was tilt(plays only radios)or sound programes

Thats the PIP (picture in picture), which lets you watch two pictures at once.  Push the PIP remote or go into the settings to turn the box off.

try hitting the PIP button on the remote, sounds like it is in PIP mode, and the vizios have many configurations of PIP

Hello! I have a 32" Vizio LCD...within 30 minutes of the tv being turned on, black lines start running through the bottom half of the screen and eventually blacking out the bottom half of the tv screen. It also doesn't have anything to do with the ratio as I have tried that. HELP!