The drivers for supported OS versions are here: http://www.epson.com/cgi-bin/Store/support/supDetail.jsp?BV_SessionID=@@@@0999257300.1292712431@@@@&BV_EngineID=ccgeademfjilhddcfngcfkmdhjidfmh.0&cookies=no&oid=14553&prodoid=21643923&infoType=Downloads&platform=All . There is a TWAIN driver for Win7 and Win Vista 32-bit. The driver for the 32-bit OS may not work under the 64-bit OS. (It is an unsigned driver but that isn't the only issue.) So check your OS version - Start > Control Panel > System and Security > System.
Microsoft says that this scanner will not work with Win7 x64 (http://www.microsoft.com/windows/compatibility/windows-7/en-us/Search.aspx?l=en-us&type=Hardware&s=Perfection%201260&os=64-bit)
If the driver doesn't work, you can try the compatibility mode (but I don't know if it will work). Right click on the file from the above link and choose Properties. Click on the Compatibility tab and select Run program as compatible with (choose an older version of Windows - perhaps XP).
The alternative that will work with most computers is to run an older version of Windows on another computer, this computer as a dual boot system, or running a virtual computer with an older version of Windows. If you have Win7 Pro or Ultimate, you can run the virtual computer for free. Download and install Microsoft's Virtual PC and then the XP mode software. For other versions of the OS, you will need a virtual computer program (Virtual PC, VMWare, Parallels) and a licensed version of an older version of Windows. Install the scanner to the virtual computer as if installing it normally. The only issue will be that you can't share files directly between the two machines. Save files to external or optical media to share them.
(You also will need a licensed version of Windows if you are going to do the dual boot or two computer option. Then install the scanner normally to the computer with the older OS.)
I hope this helps.
Cindy Wells
Go onto epsons website and download the driver or the installation file/ folder then process with any insruction enjoy
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