Hello!
Removing the hard drive shouldn't be a problem. Make sure that your computer is plugged in but the power is turned off. Rest your arms on the metal of the case to ensure you are grounded and do not fry any parts with static electricity.
Remove the drive by unplugging the molex (the part hooked in to your drive that is wired to the power supply) and the IDE cable or SATA drive cable.
If you need to plug IN a drive, that would be different and potentially more complicated but you only ask how to disconnect it. If you do need additional assistance, please let me know. If I misunderstood your question, let me know as well and I'll try to offer additional solutions.
Good luck!
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