Can I use a V220 cordless Optical mouse on a HP Desktop computer or is it only for Laptops
It will work fine on your desktop.
It is only sold as a mouse for laptops as it is compact, but it is a standard wireless mouse with a USB RF Receiver. Plug it in and it should install and run fine.
If you have problems where it isn't 100% responsive try attaching the RF Receiver to a usb extension cable so you can place it next to your mouse pad. The closer it is the better the reception.
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