Which of the two red lights is on? If it's the red paper light, it simply thinks it's out of paper. Make sure your stack of paper is properly seated in the Automatic Sheet Feeder. If it is the red ink light, it means that during a print task (printing, head cleaning, ink charging), an empty cartridge was detected. Go through the cartridge replacement procedure as described in your User Manual. If you don't have one, see:
http://files.support.epson.com/htmldocs/sc88__/sc88__ug/wwhelp/wwhimpl/js/html/wwhelp.htm
"Replacing an Ink Cartridge.
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