Here's the link to the Lexmark website on how to view the Lexmark Z645 printer User's Guide on your computer.
http://bit.ly/aXZG9o. You might want to scroll down to Maintenance or Maintaining the printer for the instructions on how to replace the cartridges. If you won't be able to view it, try the steps below.
Make sure the printer is on. Lift the cover open. When the carrier positions itself in the center, open the latch. Reload new cartridges then close the cover.
In some cases, the ink cartridge carrier won't position itself in the middle even when the printer is on and the cover is open. Just unplug the printer from the power source. With the cover open, hold the white tape in the middle inside the printer. The other end of it is connected to the carrier. Gently slide the carrier to the center. Load the cartridges. Close the cover. Plug the printer back to power source.
Hope this helps.
Leave a comment if you still need more assistance. Thanks.
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