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Out of the two blood is the easiest, fingerprints do not typically yield DNA unless skin is left behind, and live cells are again fastest and easiest. Saliva is just as good as blood and can be found many places people do not even think about such as, cigarette butts, drinking glasses, chewing gum, postage stamps, sealed envelopes etc.
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If you want your book to be lengthy, I'd recommend the computer. Writer's cramps and carpal tunnel syndrome are a definite risk when writing things on physical paper. However, if you do end up writing by hand, I'd suggest doing light wrist exercises before and after writing.
Personally, I write my best work in Microsoft Word or Google Docs. It's easier to save, and gets rid of the possibility of losing any physical papers. That being said, be sure to back up your files frequently in case your computer crashes.