Depends on what 'will not work' means.
Basics first:
1) Is the cable good - plug a USB device that you know works to your computer with the cable. Can you see that device from your desktop?
2) Is the USB port live and functional? With a known good cable and external device, does it come up? (Might combine with (1) if you can get the device + cable to come up on another computer or USB port. If it works on another system, do you get any tone or indication from your computer that something has been plugged in? Go to the USB devices page - it's in Hardware Manager in Windows, and check that the port is being seen. If you're getting a not-in-use or warning icon for the port, you may need to go update the driver.
3) If you have the documentation, or if your GPS still has a manual (or an external charger), see how much current the device draws on the USB (it should be in milli-amps or Amps (mA or A). If it's substantial, you could be overloading the USB port with the power draw. Try plugging into an external, powered USB hub that is attached to your computer. That may do the trick.
Good Luck!
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