I have a client that has a Bizhub C300 that keeps losing settings when powered off. I have read that it might be the NVRAM. Can the NVRAM be reset, or would it need to be replaced?

SOURCE: Konica Minolta Bizhub C352 error C-B116

try with trouble reset
turn off the machine, press and keep pressed utility counter, turn on the machine
on the display you'll see the Trouble reset button on the display, touch it and turn off and on the machine
check if error disappear

SOURCE: when I turn on the machine (bizhub c300) error

This is a fuser related code.
To reset the code, please do the following
1. Turn OFF the Main Power Switch.
2. Turn Main Power Switch ON while pressing the Utility/Counter key.
3. Touch Trouble Reset.
4. Check to make sure that OK is displayed and the it has been reset.
5. After turning off the Main Power Switch, turn it on again more than 10 seconds after
and check if the machine starts correctly.

Good luck

SOURCE: imaging units for Bizhub C300

There is no setting you can extend the life, however, in the service mode ( utility->meter count-> stop, 0, 0, stop, 0, 1) then press stop, 0, c. There should be a setting in there that you can disable the "image unit life end stop" setting. You will get a message every 5 minutes telling you to change the unit, but your machine won't stop working. Otherwise you can just change the chip in the image unit.

SOURCE: after update firmware on a Bizhub C350 the machine

you cannot reset nvram, you need to check your firmware. if you got the wrong fw it will do that. you can get into service mode by holding down the utility/counter button while bootup press the reset button and then press sequence for service mode initialize nvm and it will need correct fw then you good

SOURCE: konica minolta bizhub c300 how to reset fuser unit

you need to get a small pico fuse(small green resistor like part on wire harness in fuser. or if your fast you can remove the fuse and short the wires turn on the machine then count to 10 and unshort them. fuser will reset. this is the only way or get a new fuser (too spendy) write me back if you need help.