That would depend totally on your usage.
PDF Format is best for text while Tiff is mainly used for images. Windows XP Picture and Fax viewer automatically reads TIFF format. You may not have that same option with Vista and may have to download software to view TIFF extensions.
Many Businesses or proffesional (like Lawyers) use Tiff format for all their scans. Just something to keep in mind.
TIFF = large file(s)
PDF = small, compact
PDF is more commonly used today.
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