Some sort of feedback. Try grounding the input or connecting a source that is silent. If it still does it, time for the repair shop. This may be close to the schematic:
http://elektrotanya.com/mackie_swa1801_sch.rar/download.html
Scroll down to the link "Get Manual" and click to download a compressed file with two parts. One is the electronic crossover, the other is the power amp.
There is a mute control if signal is not present and also a gain limiter. This may take some troubleshooting by an experienced electronic tech. I would look for something wrong in these two parts of the circuit.
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