I replaced the power lock switch on the driver side of my chevy malibu because the locks were locking and unlocking by themselves, I also heard a beep under the dash. The problem was taken care of. Now it's starting to do the same thing. Do something need to be reprogrammed after I changed the power lock switch.

Your question as stated is missing clarity.

Do you mean power lock buttons were functional but automatic lock/unlock stopped working. Then after removing and reinserting the lock fuse, none of the lock functions work?

The BCM controls activation of all the lock actuators. The power lock/unlock buttons at the doors request the BCM to power the specific door lock with the appropriate polarity to lock or unlock. Further, the BCM has inputs from the ignition switch and the transmission selector to issue the operator programmable automatic lock/unlock.

The typical single point of failure for all door locks is the drivers switch assembly, but it requires several troubleshooting steps to isolate other potential faults.

Lock an unlock by them selves ? Door locks are computer controlled ,by the BCM - body control module .
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Power Door Locks Circuit Description
The power door lock system includes the following components:
• The door lock actuators
• A door lock relay
• An door unlock relay
• A driver door unlock relay
• The door lock and side window switches
• The body control module (BCM)
• The endgate lock cylinder switch /liftgate lock cylinder switch (utility)
• The keyless entry, if equipped
The door lock and liftgate mechanisms may be controlled by the following switches:
• The door lock and side window switches
• The BCM
• The endgate lock cylinder switch / liftgate lock cylinder switch (utility)
• The keyless entry, if equipped
The following locking functions are included on the vehicle:
• All the doors unlock -- All the doors will unlock, including the endgate/liftgate, when any power door unlock switch is detected. The passenger doors lock directly by pressing the lock switches. The driver door unlocks by the BCM using a driver door unlock relay.
• All the doors lock -- All the doors will lock, including the endgate/liftgate, when any power door lock switch is activated. All the lock actuators will activate directly from the power door lock switch (external to the BCM).
• The end/lift gate lock switch -- All the doors will lock or unlock from the end/lift gate lock switch.
• The lockout prevention -- This function will prevent the doors from automatically locking if the keys have been left in the ignition and the power door lock switch is operated.
The motor is protected by a built-in electronic circuit breaker (ECB). If the motor is overloaded or voltage is applied for an excessive amount of time, the ECB internal resistance increases, essentially creating an open circuit. The resistance returns to normal only after voltage is removed from the circuit, thereby restoring circuit continuity.

You have a bad switch input to the BCM !
Door lock acting up 2005 Chevy Malibu fix it here
Door Locks Go Crazy 2

COULD BE BAD GROUND.

You may have a bad body control module.

The locks on your vehicle are electronically controlled by the BCM - body control module . The driver an passenger door switche's are input's to the BCM . Do you know anything about automotive electronic's ? anti theft alarm remote, could this be part of the problem , No it's just a key less entry remote , nothing to do with the anti-theft .
Door Lock System Components
The Power Door Lock System consists of the following components:
• Body control module (BCM)
• Driver door lock switch
• Front passenger door lock switch
• Door lock actuators in each of the doors
• IBCM (PWR) 15-amp fuse

Door Lock System Controls
The Power Door Lock System is controlled by the body control module (BCM) and can be activated by any one of the following:
• A door lock switch Lock or Unlock actuation
• A keyless entry transmitter actuation
• An automatic door lock actuation
• An automatic door unlock actuation
• A last door closed locking (LDCL) actuation

Driver and Passenger Door Unlock Operation w/o Keyless Entry
When the body control module (BCM) detects a transition of either of the door lock switches to the Unlock position, it switches the door lock actuator unlock control circuits to voltage. Since the door lock actuator lock control circuit is at ground potential within the BCM, the driver passenger door lock actuators transition to the Unlock position.

Your best bet , take your vehicle to a qualified repair shop ! Need special tool to diagnose .

Power Door Locks Inoperative

Install a scan tool.
Turn ON the ignition, with the engine OFF.
With a scan tool, observe the door lock switch parameter in the Doors data list.
Does the scan tool display Idle?
YES - Go to Step 4
NO - Go to Step 8
4
Activate the driver door lock switch to the LOCK and UNLOCK positions.
Does the scan tool display Idle?
YES - Go to Step 9
NO - Go to Step 5
5
Activate the front passenger door lock switch to the LOCK and UNLOCK positions.
Does the scan tool display Idle?
YES - Go to Step 9
NO - Go to Step 6
6
With a scan tool, observe the driver door lock actuator command and the passenger door lock actuator command parameters in the Doors data list.
Activate a door lock switch to the LOCK and UNLOCK positions.

Sounds like the switch is bad. Try passenger side lock button or keyfob lock. If they work and not driver side, then it's the switch in the doorpanel. If none work to lock, but all will unlock, then it's probably the little lock motor inside driver door.

Intermittent door ajar switch contacts.

do you hear them trying to lock, as in a clicking noise from them, even though they are not locking/unlocking?

check wiring going to door there is a black rubber boot going to door wires have rubbed to a short. roll windows up and down if locks start working thats the door to check If one of your door locks don t work, check wiring

Hello I am not sure if this is the exact fix but I was having the same problem and I took my Malibu in to be checked and it appears to be a problem inside the steering column. When I turn the steering wheel it makes the door locks go crazy!! So although this is not a fix it may be a place to look for a frayed wire or a short in the wires. I am taking my Malibu in on Monday to be checked. Good luck to all having the same problem.