Read through the discussion at the internet link below, and it may help you fix this.
https://archivehistory.jeksite.org/chapters/scan_part5.htm
Quoting:
Other> Save settings: saves the settings and preview when Epson Scan is closed and is usually convenient.
The button for File Save Settings to the right of the Scan button determines the folder, file name, and format for the output files. The Location section of the dialog box specifies where the output files are written. I normally select the Other button and then Browse to identify the folder.
The output file names are limited to a prefix and number. The prefix can be set to identify the image. The added number is usually not needed and can be removed by renaming the file after it has been created.
The field for Image Format includes the usual TIFF and JPEG. Note that plain TIFF should normally be used for archival scanning, not the Multi-TIFF option.
The checkbox for "Show this dialog box before next scan" can be checked to give the opportunity to set the output file name for each scan. As noted above, the prefix part of the name can identify the image.
The checkbox for "Open image folder after scanning" can be checked to provide the opportunity to examine the final image and rename the output file.
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