For reference, specifically, this would be indicative of an alarm on the motherboard.
The only typical alarm of this nature would be an overtemperature alarm, either for chassis or (more typically) CPU temperature.
In this case, it sounds like the CPU fan was failing, causing the CPU to overheat; once the threshhold temperature was reached (BIOS configurable), the alarm sounded.
Remember, boys and girls, if your computer is making a sound like an ambulance, there's probably something bad going on.
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The sound you are hearing is a warning that the CPU is over heating.
Try cleaning the CPU fan & the heatsink the fan is connected too.
If you built the system did you add thermal grease between the heatsink & CPU?
It is also possible the thermal grease has dried up & is no longer allowing the heat from the CPU to transfer to the heatsink. It may be time to replace the heatsink assembly.
If your over clocking the CPU reset it to normal.
Does it shut off with absolutely no warning sounds whatsoever?
Do you ever hear a faint PC beeper alarm that kinda sounds like a ambulance siren (you know... kinda like a WEEEE. ORRRRR... WEEEE... ORRRR)
My main suspect at this stage is OVERTEMP (you are overheating the CPU).
Possible Causes: Recently UPGRADED components (especially VIDEO)
Build up of dust in Case and CPU heatsink and GPU heatsink or CPU fan has failed or one or some case fans have failed.
Do you know how to check your CPU temp in BIOS? If it happens again check it out.... greater than 90 degrees is usually bad.
Check all your fans are spinning, check you don't have 'caked up' dust on your heatsinks.
If you have recently upgraded a major component that is dumping heat into you case... investigate a new case fan to extract this heat (cheapest option) or you may want to pick up an aftermarket CPU heatsink and fan (Thermalright FTW!!!!!!!)
Alright, this sounds like the board was DOA (Dead on Arrival). Unfortunately it sounds like you will have to contact ASUS and request an RMA or a refund. This has been happening more often with ASUS products recently and is definitely a pain.
Dual-tone siren meaning - hardware monitoring signalyzed that some problems with mobo, to ex.: - any Voltage (CPU, RAM, chipset etc) is bad - any Temperature (from any sensor) is bad - frequency of cooler is bad (or not connected)