Can I use micro SDHC on my sansa e250 if yes how can I Do it.

Make sure the card is a microSD card, not a microSDHC card. The e250 only works with microSD cards, 2GB and smaller.

From your description, you seem to have bought a regular SDHC (secure digital high-capacity) card. A Sansa Fuze can only accept micro SD or micro SDHC cards. For buying a new card, I would suggest this card from newegg.com. As for other things you mentioned: No, the card you bought is not meant for cameras only, the only reason your device uses micro SD/SDHC cards is because it is a smaller device. The 4 on your card signifies that it is class 4 which is the card's speed classification.

The e250 works with microSD cards. Your 8GB card is actually a microSDHC card. While physically identical, microSDHC cards are electronically incompatible. You need to use microSD cards 2GB and smaller.

Hi!
Is the new card a normal micro-SD card - or is it a SDHC card??
Pay attention to your player version, as only v2 (e250 v2) supports SDHC cards. For v1 you'll have to use a standard micro-SD card.
If it DOES support SDHC cards, or it's not a SDHC card, then:

• Have tried using another card to see it the device is not damaged and that it still have the ability to read micro-SD cards?

• Have you try using your own card on another device (PC, cell-phone, other player, etc.)? Did it work (Check for SDHC compatibility in this case as well...)??

FYI, SDHC stands for Secure Digital - High Capacity.

Hope I helped,
Pelu.

Yes it does have a slot for microSD card on the right side

Is you E280 V1 or V2? The V1 will only recognize up to 2GB. You can find this by going to settings, info. If the firmware number starts with 1 it's a V1. V2's start with 3.

If you have a V2 place the card in a card reader to format. Format card to FAT32. If not recognized by a card reader the card may be defective.

If the player is a V1 the micro SDHC can still be used by loading RockBox firmware. But note when running RockBox the sync port will be disabled. To use port the player can still be started in the Sansa firmware but a SDHC card will not be accessible.

http://www.sansaworld.com/
http://www.sansaworldmp3.com/

Check the Sansa tutorials at http://www.sandisk.com/Retail/Default.aspx?CatID=1468
to make sure you have followed all the steps first.

In my experience, every mp3 player/photo frame/etc with a card reader has a MAXIMUM memory limit for the type of card that it can read. It is possible that the Sansa player can only read 2GB Micro SD cards or smaller - and thisi nformation may not have been available when they printed the manual. If you have followed all instructions, and it still will not read the card, try switching to a 2GB Micro SD card.

I don't think that the sansa e250 supports sdhc cards these cards 4gb and up are only compatible with newer electronics

If the 4gb micro SD is a high capacity SD (it will say micro SDHC on it) your player may not be able to read SDHC cards, my sansa can't because it's the 'older version' it will read 2gb and below micro SD cards though (it sucked when I found out because I had just bought a 6gb micro SDHC)

Go to the knowledge base on the Sansa site and find this (chances are you have an SDHC card in an incompatible unit):
Sansa e200 - verify the version of the player.  To check, go to SETTINGS > INFO. 
              
For 01.xx.xx firmware (e200 version 1) - up to 2GB microSD cards 
For 03.xx.xx firmware (e200 version 2) - up to 16GB microSDHC cards 
NOTE: Firmware is not interchangeable. 

Sansa e200R - up to 2GB microSD cards 

Sansa e100 - supports SD cards up to 2GB