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I have had this problem numerous times. It's a glitch in the game, best I can figure. It corrupts your saved game. You might be able to go back to an earlier save and play from there. But the best solution, if that doesn't work, is to take out the game disc, turn on the ps2, click on Browse (with your memory card plugged in) and delete the Vice City file(s) on there. Then put your disc back in and start over from the beginning. It sucks, I know. I've had to do it. And once I was almost to a 100% completion. Bleh. =( Sorry.