What error-message(s) do you get when you try?
If you're referring to the _free_ Acrobat Reader,
use Add/Remove Programs to uninstall it.
Then, download the latest version of the software from
http://www.adobe.com -- most of the updates will already be integrated into the download.
If you're referring to the "full" software (that creates PDF files), find your original software, and license-key. Then, use Add/Remove Programs to uninstall it.
Restart your computer.
Reinstall from the media, using the license-key.
Then, do the "check for updates" within the software.
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