Here's my shortcut:
Try this: disconnect the player from the computer, turn it off, hold in the volume + button, and reconnect the player to the computer while holding the volume + button in. Keep holding the volume + button for an additional 5-50 seconds. Windows should eventually go into recovery mode and revive the player- it will pop up a window that says Found New Hardware Wizard
Here is a suggestion from the iRiver website - you may want to visit that website, b/c their "Ask Alice" tech support feature is actually quite good:
The players come with a CD that contains drivers and software that
enable the player to download data from a PC. Insert the CD in the
computer's CD drive, and connect the player to the PC with the USB
cable. (Help with USB cable connections
PC should automatically detect the device. The New Hardware
Installation Wizard will automatically launch and the installation
process will start.
If the above procedure does not occur on your PC, please manually install the driver. Use the links below for instructions:
you still have trouble, the issue may be with the computer chipset.
iriver has tested many PCs and discovered that this only occurs in a
small number of main boards.