You haven't given us much information... You obviously have some sort of feedback and saturation in process. First thing is to unplug ANY signals into the unit including any inserts and see if problem goes away. If it does, start adding them back in. If it doesn't go away with only the main outputs then VERIFY that you are using BALANCED interconnects to your amps/speakers AND that the mixer AND all of these amps/speakers are powered from the SAME receptacle or power conditioner module. If the BARE mixer with only headphones has the problem, then you have a power supply in the mixer that is squeging.
My pa28 makes noises to and seems to get worse when it's humid outside . What I do most of the time is I keep the mixer in my air conditioned house and leave it on for a couple of days before a gig and that's been working for me
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