I ASSUME that you plugged your guitar into a DI box that then used BALANCED XLR cable to the Mackie board??? The guitar generates line level and the Mackie board inputs are mostly mic level... you will get distortion if you overdrive the Mackie board. You could try going into line level jacks, HOWEVER if you go any distance balanced interconnects must be used. Even the line level jacks require using TRS balanced cables. Try is using a DI box, and preferably one with a gain switch. Also fiddle with the ground lift switch on it for least noise or hum. I use the LiveWire brand DI boxes and they seem to work fine. Then it is important to set the gain with the trim on the MAckie so you don't clip. Also be aware that an acoustic guitar can "hear" speakers and you can get feedback or regeneration that will sound like you are in a cave.
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