20 Most Recent MSI MS-6378 Motherboard Questions & Answers

Not trying to be trite sir, but I think that is a broad unsupported statement........

If we look at the known universe...........

!O_O! What a minute?...........What?............Oh........

...fans, video card, cpu, ram, cd drive, hard drive, and power supply work; (Semi-Colon), as well as the motherboard itself...........

With all due respect what do you base all that diatribe on?

Fans spin, and LED's light up; and you're going to assume the other hardware components, must be working as well?

THAT, is your basis for your hypothesis?

A) You can see the fans spin......

B) You might hear the harddrive spinning it's platters, while it is in an endless loop............

C) You can press the optical drive's (CD/DVD drive) tray release button, and open the tray.......(To assume it's getting power)

But tell me how you assume the cpu, motherboard, ram memory, graphics (video) card, and Power Supply; to be good?

What do you base this assumption on?

With all due respect..............nothing.

Your observations are baseless.

Seem like I'm trying to be rude?

No sir. Trying to get you to think outside the box

What is the common 'denominator' here?

What hardware component is common to all the others?
That........if not working at full capacity, would not allow the others to work?

The motherboard is the 'Building Block' of a computer.
The CPU is the 'Brain'
The Power Supply is the 'Heart'.

No 'heart' you have nothing.

When diagnosing desktop computer failure, the first hardware component to diagnose; is the Power Supply.
Without it operating at full capacity nothing else works.

Past this point the diagnosis can go on. (Power Supply deemed to be good)
If not you will be pulling your hair out searching for answers.


1) If ALL of the LED's were on at once, they would use less than 1 Watt of power.

2) EACH fan uses 2 to 3 Watts of power.

3) A typical CPU (Processor) can use 51 to 130 Watts of power.

A Power Supply with a weak voltage power rail, will have power to light those simpy LED's, and maybe spin fans; but will not have enough power to turn the CPU -> ON.

Have an economical multimeter?
They range in cost from $5 to $12, usually.
I have seen them on checkout aisle racks, at major discount stores.
Auto parts stores have them, but usually more expensive.

With it you can test the 3 main DC Voltages, coming out of the Power Supply;
3.3 Volts
5 Volts
12 Volts

Again, all are DC Voltage.
In comparison two D cell flashlight batteries produce 3 Volts DC.
(The dangerous AC voltage is kept contained, in the metal case of the Power Supply)

Use a KNOWN to be good, Compatible power supply for a test unit.

("I need to borrow the Power Supply out of your computer honey.
No, no.......I'll put it back. This shouldn't take long.
What? Touch it, and I'll lose sum fingers?" )

Also, follow Anti-Static Procedures, and look at the Electrolytic Capacitors on the motherboard.
In fact, what the hey right? Might as well look at them first,

A) http://capacitorlab.com/visible-failures/index.htm

B) http://www.youtube.com/watch?v=Lut7MX5Dd_A

Capacitors on the motherboard are used as Filters, or Voltage Regulators.
The ones used as voltage regulators are in the
Motherboard Voltage Regulator Circuit.

Part of what the motherboard voltage regulator circuit does, is regulate voltage for the processor.

The processor MUST have a steady, 'clean', supply of voltage; and it MUST be kept within the tight voltage tolerance range, for the processor.

Too little, or too much, and it turns off. (BIOS turns it off)


(For older motherboards, and to include older server computer motherboards; voltage regulation for the processor was accomplished with a VRM. Voltage Regulator Module.
A separate, replaceable 'card' )





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(One last little item that seems to slip through the cracks, the Ram Memory. Clean the gold plated contact pins with a pencil eraser. Use air to remove the eraser dust )

MSI MS-6378... | Answered on Mar 30, 2013

Download the manual here:Manual

MSI MS-6378... | Answered on Jan 26, 2012

Get the user manual here: User Guide
Chapter 2 Page 17.
The plugs just fit on to little pins in the bottom corner of the board.

If you connect them and hard drive indicator light on the front of the case does not come on then you need to swap the 2 connectors around.
It's an led which has to be connected the correct way to work.
Same goes for the power led on the front of the case.

MSI MS-6378... | Answered on Jan 26, 2012

Hello, you can download the manual here:


Unzip the file before you can read it.

MSI MS-6378... | Answered on Nov 28, 2011

The motherboard model that you listed doesn't have support for SATA drives. Are you sure that's the correct model? If so, that's your problem, unless you are using a third-party SATA PCI controller. Then I would need to know the model of that to find the driver you are requesting.
I know this doesn't answer your question, but if it helps please rate positively.

MSI MS-6378... | Answered on Jul 01, 2011

To reset BIOS take the battery out, if that does not work you will have to reset jumper J1. In case nothing worked to reset BIOS you can use thrid party software from Hiren's Boot CD to reset the password. You've got Kill CMOS on there, for example which wipes out CMOS. Here's the download link to the entire CD: http://www.hirensbootcd.org/download/Hirens.BootCD.12.0.zip

MSI MS-6378... | Answered on Nov 30, 2010

Search for your MOBO SPECS.

MSI MS-6378... | Answered on Oct 21, 2010


MSI MS-6378... | Answered on Oct 05, 2010

Here is the link to your motherboards manual, front connector info will be in there http://eu.msi.com/index.php?func=downloaddetail&type=manual&maincat_no=1&prod_no=283

MSI MS-6378... | Answered on Jul 15, 2010

your board has an IRQ ( Interrupt request ) issue possibly a video card that is in conflict with a mouse device.

MSI MS-6378... | Answered on May 29, 2010

This is what I would recommend:
First, unplug the computer from the power outlet. Then re-plug it and try to start it. If nothing seems to work, but you have power (you can hear the fans start and hear the hard drive spin up, you can open the case and disconnect everything BUT the CPU, memory, and video. See if it starts. It should start up with video and give you an error saying something about no boot device. If this is the case, then start plugging things in starting with the hard drive.
If it doesn't work your power supply may be bad. If you have another to swap out, that's good. If you don't, then you really can't check it without a power supply checker.
If this doesn't work you are probably looking at a bad motherboard, bad CPU, or bad memory.

MSI MS-6378... | Answered on May 12, 2010

A great program to run to identify your motherboard would be CPU-Z. You can visit the website here: http://www.cpuid.com or you can download the No-Install tool here http://www.cpuid.com/download/cpuz/cpuz_154.zip

Just unzip the program to a folder on your desktop and run it...it will tell you your motherboard model.

MSI MS-6378... | Answered on May 02, 2010


• Support Socket A for AMD® Athlon™ / Duron™ Processors
• Supports 600 ~ 1.3GHz (PCB Ver1.x & 2.x)
• Supports Athlon™ XP 1500+ ~ 2000+MHz Processors (PCB Ver2.x only)

Manual here:

MSI MS-6378... | Answered on Apr 04, 2010

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