Try this from "Tom's Hardware" worked for me!
1) RIGHT-CLICK on the MY COMPUTER icon and click on PROPERTIES.
2) Select the HARDWARE tab, then the DEVICE MANAGER button.
3) Remove the Epson
Scanner from under IMAGING DEVICE and/or UNKNOWN and/or
OTHER DEVICES by RIGHT-CLICKING on it and clicking UNINSTALL.
4) Disconnect the USB cable and close all open windows.
5) Click on START, and CONTROL PANELS.
6) Double-click on ADD/REMOVE PROGRAMS. Highlight EPSON SCAN and click on
CHANGE/REMOVE.
7) Go to START, SEARCH, and ALL FILES AND FOLDERS. Select Advanced option
and ensure there is a checkmark next to SEARCH HIDDEN FILES and FOLDERS.
8)Search for files where all or part of the file named is OEM*.* and a word
or phrase in the file contains EPSON. Search location should be set to
C:\WINDOWS\INF or C:\WINNT\INF.
9) Delete all files that are found if this is your only Epson product. If
you have another Epson product, you will want to open each individual file
and determine which files pertain to your scanner, and then delete only
those.
10)Go to START, SEARCH, and ALL FILES AND FOLDERS. Search for files where
all or part of the file named twain.log . Search location should be set to
C:\. Please delete the twain.log file and repeat the process for
twain001.mtx, twunk001.mtx and twunk002.mtx. and epfb5 and escndv
Now we need to remove specific references to the product in the registry:
1. Click on START and then RUN.
2. In the Run window type in REGEDIT.
3. In the upper menu bar click on FILE, then EXPORT.
4. In the window that comes up, SAVE IN should be set to DESKTOP.
5. In the FILE NAME section at the bottom of the window type in REGBACKUP.
6. EXPORT RANGE should have a dot next to ALL.
7. Click on SAVE.
8. Look in the column on the left and Click on the "+" sign next to
HKEY_CURRENT_USER
9. Click on the "+" sign next to SOFTWARE
10. Click on the "+" sign next to Epson
11. Look for a folder name EPSON SCAN or epson twain . Right click on it
and Delete it (if you don't see it, then don't worry about it).
12. If you see a reference to your Epson product model, right click and
delete it.
13. Click on the "-" signs next to EPSON, SOFTWARE, HKEY_CURRENT_USER to
close up this branch.
14. Click on the "+" sign next to HKEY_LOCAL_MACHINE
15. Click on the "+" sign next to SOFTWARE
16. Click on the "+" sign next to Epson
17. Look for a folder name EPSON SCAN or epson twain , Right click on it
and Delete it (if you don't see it, then don't worry about it).
18. If you see a reference to your Epson product model, right click and
delete it.
19. Click on the "-" signs next to EPSON, SOFTWARE, HKEY_LOCAL_MACHINE to
close up this branch.
DOWNLOAD
Please follow the steps below to download and install your scanner in XP:
1. Go to the website
http://support.epson.com 2. Under the SCANNERS heading select PERFECTION SERIES and then your
scanner model.
3. Under the Drivers & Downloads section select Windows. Download the most
current version of the
Scanner Driver for your Windows operating system to
your DESKTOP.
Reinstall
1) Double Click on the Epson1****.exe file that you downloaded to your
DESKTOP.
2) Click OK, Unzip, and then OK again.
3) The installer will copy the files to the system. Click on FINISH when
prompted.
4) Connect the USB cable to a different usb port on the computer. Windows
will tell you new hardware is found and complete the install.
5) If a message appears indicating THE SCANNER HAS NOT PASSED WINDOWS LOGO
TESTING, click CONTINUE ANYWAY. Then click FINISH.
6) Your scanner is now ready to use
