Cuisinart dgb-650
In an empty machine,(no coffee, no filter), pour in a 50-50 mixture of water and white vinegar. Allow the machine to start brewing and when a cup or so has run through, stop the brewing process and let it sit for an hour or two. This should dissolve some of calcium buildup in the machine and allow it to complete a full cycle. May have to do this a couple of times to fully clean out the mineral buildup. After cleaning, run a pot of clear water through to rinse out the remaining vinegar.