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A tune up consists of replacing the spark plugs and maybe the spark plug wires. Change the air filter too. No need to do timing. It is controlled by the cars computer. Spark plugs should last for about 100,000 miles. Air filters vary on how long they last. Check the air filter at 25,000 miles. Replace it no longer than 50,000 miles. Your car should not need a tune up for a couple more years or so.
The most common cause for loss of mileage is the engine not being properly tuned. Resrtricted air filter, spark plugs, dirty injectors, dirty egr valve, fuel filter, under inflated tires. These are the basics....I hope this helps.
There are several issues that can cause poor gas mileage. I suggest you perform ( or have performed) a tune up. Filters, Fluids, Spark Plugs, Wires, Belts, etc.. & see if that improves your fuel economy...
New spark plugs, oil and oil filter, transmission flush and fill, fuel filter, air filter, coolant flush and fill, clean throttle body plate and bore, clean the MAF sensor, replace any loose or cracked vacuum lines, PCV valve, new air filter, new battery.
99% of the time all you should ever need for a tune up is new spark plugs, and a clean air filter and throttle body. But since your inquiry indicated "major" I gave it more critical thought.