1995 lexus ls 400 multi cylinder misfire 2 4 6 8 running very rich burning gas out types

have a compression test done as I suspect a head gasket or cracked head

Sounds like a bad coil. i would swap the coils to run 2,4,6,and 8 and see if those started to misfire. If 1,3,5,7 still misfire I would do a compression test. Has the timing belt been replaced yet.

Up to this point in time, mechanic 1 has only done some maintenance work on the car. Things that would be done from time to time to maintain the car.
Since you have lost trust in this mechanic, I would go to a different place and have them diagnose the codes. If the second place gives you the same recommendation you can decide what to do.
You can tell the second place you are getting a second opinion, or not.

Please click this link for diagnosis and repair of engine misfires, all the info you need to isolate the causes is listed, it is allot of great information.

If the ecm didn't fix it, I would have your ignition system checked, could be a bad ICM or a bad coil maybe. If you haven't already checked the spark plugs and spark plug wires. Did you have the ECM programmed for your car?

P0301 Cylinder No. 1 Misfire Detected
P0302 Cylinder No. 2 Misfire Detected
P0303 Cylinder No. 3 Misfire Detected
P0304 Cylinder No. 4 Misfire Detected
P0305 Cylinder No. 5 Misfire Detected
P0306 Cylinder No. 6 Misfire Detected
P1346 Variable Valve Timing (VVT) Circuit Range/Performance Fault
P1349 Variable Valve Timing (VVT) System Malfunction
P0330 Knock Sensor
P0446 EVAP Vent Control Fault
P0430 Catalyst System

Stop driving immediately.....

You defiantly skipped on your timing........

cylinder 4 misfire detected Start with the easy things.....Wires and plugs

try removing and cleaning the mass air flow meter as this controls the fuel delivery if problem persists replacing the distributor might be the solution the pick up plate inside could be bad.

MY LS-400 IS RUNNING HOT WHAT CAN I DO TO SOLVE THIS PROBLEM