Misfire sometimes it runs good then misfirers sometime it runs smooth at 1500-2000 rpm sometimes not help me please thanks

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You'll have to figure out if it is fuel or ignition related to proceed.
Could be injector problems, or spark problems.
Did you have the computer scanned for trouble codes ?

P0300 is a random missfire code. What exactly would you like to know about it??

sounds like a vaccum line or once again tps/poss timeing off

Hi, my first recommendation would be to take the plugs out and visually inspect each one and check to make sure they are properly gapped, if they look fouled at all i would replace them without hesitation. try throwing a set of NGK plugs in the car to fix the misfires. other than that you may want to look at the wires. good luck joe

CODE PO300 MULTIPLE ENGINE MISFIRE DETECTED CONDITIONS. CODE PO506 IDLE SPEED TOO LOW CONDITIONS.LOOKS LIKE THE IDLE SPEED CONTROL IS NOT WORKING.

P0300 is misfire and p1406 is EGR. It sounds like you have a chunk of carbon stuck in the EGR valve. Remove the valve and clean the carbon from the valve, bottom side. Then install a screened gasket so it won't happen again.

P0300 is a random engine misfire code. P 1781 is a transmission code, but it refers to a malfunctioning engine speed signal (crankshaft angle sensor). A bad crankshaft angle sensor or camshaft angle sensor can cause the P0300 code. A large list of items can cause a P0300 code, but since you have both, I'd be checking the crankshaft angle sensor and the related circuit. Sometimes, the mounting screws loosen up, which can cause the sensor to not function properly, all the time. Get this fixed, because over a period of 4 to 6 months, this can destroy the catalytic converter in the exhaust system ($$$$)
Charlie

HELLO. WELL YOUR ALMOST RIGHT,. WHAT YOU NEED TO DO . IS CHANGE YOUR MAP. CENSER'S . AND THAT SHOULD DO THE TRICK . WELL HOPE THIS HELP'S YOU , GOOD LUCK

Have you replaced the coil yet? I assume by all 4 cylinders misfiring you mean P0300 Random Misfire? It could be a number of other things - a faulty fuel injector, coil, etc. Read this article for more info on random misfires - http://www.obd-codes.com/p0300