What is the easiest way to replace fuel pump on 1998 isuzu hombre; take bed off or drop the tank?

my guess you mean the fuel inertial crash valve.?
like many fords have.?
seems some Isuzu do too.

if you were to follow the tank pump pressure line, forward.
it may be there, just look, no need guess, or ask us to guess.
as some cars have it, depends on engine type and fuel system options....
the FSM book cover this, and even tells you which engine options have it.

remove the fuel filler and breather from the fuel tank, unclip the rear wiring harness to the rear lights and numberplate lights. and then locate the bolts that attach the tub to the chassis I think there are about 6 or so. when lifting up the rubber blocks may fall out but keep them with the bolts for later use . that should have it done as long as you have some one to help lift it out. hopefully that gets you on your way

Fuel pressure regulator is going bad, basically you are getting to much fuel into your cylinders and are causing hydro lock

Usually you do not remove the bed, but rather drop the fuel tank. Everything should be accessable then.
But, the bed just unboltst and you release all of the wires. A bed often gets damaged during removal, so I suggest that you drop the tank and do your repairs from the underside. It will be faster and easier.

if u took the bed off make sure the ground is hook back up to the frame that should allowed the pump to come on.need to change the fuel pump relay when changing fuel pump,that could be why the pump stop working before u change the old pump.

Bad sending unit attached to fuelpump or most likely a crimped or chaffed wire to it, either inside the tank or outside.

drop the tank is the best way to replace pump.

electric fuel pump is in that gas tank. you can do this 2 ways. one is take the bed off. un hook all your wires and remove the bolts out of the bed then get 3 buddies and remove the bed. so you can get to the top of the tank to get the fuel pump. or you can get a floor jack and support the tank and remove the tank straps and slowly ease the tank down so you can unhook the wires and hoses. then remove the tank all the way and work on removing the pump.

the fuel gauge should not be replace as it should be only one for both tanks when you switch tank selector the wiring also switches so you get reading from the tank you are using .now to replace the fuel pump you have to drop the fuel tank, some people say its easier to remove the bed but i disagree. hope this helps you

It could be the fuse for the fuel pump or the fuel filter.