2000 f350 no brake lights or cruise

Due to its age and probable high mileage, I would look for damage to the lighting loom feeding the rear indicator and brake lights.

You have a short to ground on that circuit , you need to look at a wiring diagram an see what all is on that circuit . It's hard to get out of park because this circuit supply's power to the shift interlock actuator . You don't need to step on the brake pedal for this fuse to blow ? just stick in a new one an it blows ? This fuse also powers the brake switch , which powers your brake lights . Electrical Troubleshooting Basics EricTheCarGuy If you have not had any experience in electric trouble testing you may want to take to someone who is !

hot wire touching metal fuse blows so you don't burn up the wiring get it tested and fixed soon could be dangerous to keep putting in a new fuse

This all depends, if the fuse blows as soon as you put it in without stepping on the brake pedal then theres a dead short in the fuse box or the power wire going to the brake switch is shorting out, this 15amp fuse runs from the fuseox to brake light switch, so the short is between that but if it blow with brake pedal pushed then you said you dissconnect the rear brake light at fuse box and fuse still blows so the next step inwhich power is feed from this fuse is the following and you will need to unhook these components one at a time until short is gone. the next location is the the abs brake control module which is by the master cylinder area after that it goes to the cruise contorl servo also under the hood, then it goes to the shifter release solenoid which is very common problem, the wires melt or short out in that area, and next it goes to computer which i dont think is the problem and from there it feeds the rear lights and third brake light. hope this helps, good day.

You may have to replace your "clock spring" in your steering wheel, this works the horn and cruise control and air bag.....Thats the only thing i can think of...when you turn your wheel....

i would look at the brake pedal sitch for chffed wires or shorted to ground

It is the fuel heater, All you have to do is unplug it.

It will be the brake switch that the pedal operates. It may be that the same switch is used to de-activate the cruise control when on. And it's on the same circuit as the horn, so when you have no horn, you know you've got no brake lights. Go to you Dealer and get a new switch - they have been modified a long time ago.

Please check the brake light wiring there must be somewhere where the live wire is touching the body (earth -) and thus the blowing of the fuses.
Since the plug in had melted so must have the wires insulation top melted somewhere and its now shorting.
Hope this helps.

Start by replacing your brake light bulbs. If it still blows the fuse, them your brake pedal switch. If it still happens then you have a shot circuit in your wiring between your fuse panel and your brake lights.