2009 sienna setting c.e.l. light multiple missfire codes

I guess my original post was insufficient. When the light sets, and is blinking, the engine runs very poorly. As soon as I pull over and shut it off, upon restart it runs perfectly. I have driven it over 300 miles after light set without it setting again. Every time the light has set, we were driving on Interstate with a 70 mph speed limit. The light would usually set again if we crept up to 72 or 73 mph. The codes keep jumping around, but never has set any codes other than the specific cylinder misfire codes. Never any EGR MAF O2 sensor codes. I guess my original post was insufficient. When the light sets, and is blinking, the engine runs very poorly. As soon as I pull over and shut it off, upon restart it runs perfectly. I have driven it over 300 miles after light set without it setting again. Every time the light has set, we were driving on Interstate with a 70 mph speed limit. The light would usually set again if we crept up to 72 or 73 mph. The codes keep jumping around, but never has set any codes other than the specific cylinder misfire codes. Never any EGR MAF O2 sensor codes.

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