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lol no it has nothing to do with your bios. I'm surprised that if you know your way around a bios that you would head there. You need a driver for the mouse. In case you do know more than i am giving credit then here's what to do if you already have the driver. Go into device manager and delete anything under the mouse section that is not your touchpad. then plug the usb mouse back in.
Are you using XP? If so: Here is what you can do to refresh the USB ports: 1. Right click MY COMPUTER 2. Select PROPERTIES 3. Select HARDWARE 4. Select DEVICE MANAGER 5. Select UNIVERSAL SERIAL BUS CONTROLLERS 6. Right click on each USB CONTROLLER and select Uninstall 7. Uninstall all entries 8. Reboot your computer 9. As your computer re-boots it will reinstall all USB connections it detects THEN, when all other USB items have been configured and connected by the system, you then should try connecting your USB device.
If I could be of further assistance, let me know. If this helps or solves the issue, please rate it. Thanks, Joe
Two solutions would be to either restore your pc to before the problem started,using system restore on accesories menu, or use the recovery cd or the recovery folder Acer laptops usually have on the 'D' drive and re-install usb controllers and drivers.