I have a Lacie 4TB 4Big Quadra drive. One of the LED's on the back flashes RED... however, the front light is still BLUE. This light sequence is not on the Lacie matrix of light scenarios.... If I replace the drive in that bay with a spare, the Lacie product goes through the 'replication' process (Raid 10).... when it completes, the indicators have returned back to the 'problem' as outlined above.

SOURCE: How to format the LaCie 500GB d2 Quadra for Windows XP??

This way it should work...
Connect your drive to the computer...
Go to: Start > Control Panel > Administrative Tools > Computer management.
A new window will appear...
Select Storage > Disk management on the left of the window.
Now you will see the different drives that are connected or part of your system.
One of the drives listed there is your LaCie, i think you'll recognize it by name...
Right-click on it, and select 'format'
In the new window, select the new volume label (as you like it), the file system (use NTFS), and set allocation unit size to default.
Make sure 'Perform a quick format' is not checked...

Then click OK. Your drive will be formatted now... Don't interrupt the process

SOURCE: Lacie 2big Triple 2T - Raid 1 LED's blinking

Solved! After 17 hours of blinking, the status of the 3 leds is now to fixed blue. You just have to be patient...
Note that I had only put 1GB of data on the drive. I expect that the resynchronization time is not proportionnal to the amount of data on the disk!

SOURCE: deference Lacie d2 Quadra1TB/Lacie big disk ?

It's all about the interfaces.
The Quadra has four interfaces: • eSATA • FW 400 • FW 800 • USB 2.0
The triple has all but the eSATA interface listed above.
For doing video work you want a big drive with a fast interface. If you have eSATA available then that's the fastest. If you don't then you're just as well off to go with the triple interface. The FW 800 would be the next fastest, then the USB 2.0, then the FW 400.
Because of the way that data is transferred I believe that when doing video work you would be best served by the FW 400 instead of the USB 2.0 even though the USB is faster I don't believe it is a full duplex communication so the FW 400 is actually better for video.

SOURCE: My LaCie 500GB Quadra spins and clicks. Have tried

If you can hear clicking then I am afraid there is a serious problem with the hard drive.

The noise you can hear is usually known as "the click of death" when referring to hard drives.

Make sure you use ONLY the cable that came with it or a SHORTER one.

Dont connect via a USB hub

Make sure you only user the power supply that CAME WITH IT.

Most common causes are that the drive unit was dropped or mishandled or just plain old age

There is no known cure unless the data is mission critical

In which case you could sent it to a data recovery specialist but this is usually VERY expensive.

If you are advised to place it in a freezer or anything similar then that is up to you
but my advise would be to run from the person who may give this advise.

This is very old fashioned advice and meant for very old types of drives that used to get very hot.

If it a drive that was / is from an external enclosure then you could still use the enclosure and just place a new hard drive in there.

Another way to test it it to remove it from the enclosure and connect it directly to a PC with a suitable interface eg. SATA or IDE.

Testimonial: "Thanks for the quick reply. "

SOURCE: 4 big quadra 6 TB,

The hard disk might originally came from a computer with raid 0 configuration that is why no matter what you do to reformat, it will always give you the same drive space as your Raid 0. The solution to your problem is actually deleting the partition first from another computer before formatting.

You will be needing a windows installation disk and you can plugin the big quadra thru the usb cable in another computer. Run the windows installation disk (this could be xp or vista) and when it prompted you to choose a task, just press enter to start windows installation (DO NOT press R to go to recovery console). Next, the system will search of every available partition and will show you the drive partition for your Big Quadra. Select for it and delete the partition from there. After it has been deleted, you can cancel that installation process from that computer and try re-formatting your drive into Raid 5 again as you have been doing before.

Should you have any question, please feel free to ask. Good luck!