If I replace my own battery in a 2006 Honda Accord. Is there any programming that gets lost and needs to be redone?

Get a memory saver from walmart for a few dollars or so. It plugs into the cigarette lighter and will prevent memory loss from changing the battery which will otherwise erase the radio codes and render the radio disabled for anti-theft reasons.

If your battery does die, and goes below a certain voltage, then go to the honda.com website and look under the 'owner's' section and follow the procedure for entering the radio code after you have supplied the website with the information from the owner of the vehicle.

Good luck on changing your battery without losing electronic device memory.