First make sure your have downloaded all automatic updates to Vista. You may find that a game that was not compatible will now load. If that doesn't work, try a patch for the game. http://askville.amazon.com/OREGON-TRAIL-VERSION-GAME-COMPATIBLE-WINDOWS-VISTA/AnswerViewer.do?requestId=13345235
If all else fails, you can purchase newer versions here: http://www.kidssoftwareoutlet.com/Oregon-Trail-s/144.htm&Click=6972
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