Normally just running a good virus program will remove viruses. There are many newer super hard to remove "Pests" and newer ones come out all the time. If your hard drive has lots of particularly heinous viruses on it the best thing to do is to repartion the drive then reformat it. Noting can survive this process, then reinstall the operating system. You can also get a boot disc from your anti virus source and boot it and run the antivirus program without running windows.
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