Under the mouse there should be a usb stick attached to the mouse which most likely should slide out from the mouse. It also appears that the plastic cover behind the two buttons (this cover has targus written on it) Should come off. After you remove the usb stick there might be a button somewhere on the bottom of the mouse that you should be able to press to get the battery cover to pop up. Then you should be able to pull up on the battery cover and remove it from the mouse. This mouse takes two AA batteries. Once the batteries are installed then plug the usb stick into any of the usb ports on the computer. The computer should recognize the drivers for this mouse (if you are using Windows 2000, XP, Vista, or Mac OS X [or higher]). If the drivers are not immediately recognized then restart your computer and the computer should then recognize the mouse. If this still does not happen then let me know. Also there is software that can be downloaded from the Targus website for the tilt wheel as it has some added capabilities that can be set using this software. The link for that software is here ------> http://www.targus.com/us/product_details.asp?sku=AMW26US
I hope this helps, and enjoy that mouse, it looks pretty nice!