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do you have a wired or wireless mouse? Have you tried attaching a different mouse to your computer? What is the brand name of your mouse?
Try booting your computer in Safe Mode. To do this, after turning on the computer, press F8 button several times. You will see a screen that will ask you to boot normally, boot in Safe Mode or boot in Safe Mode with Network Connections. Select Safe Mode.
See if your mouse works then.
Check back with me for further help, if needed. There are additional things you could try.
If your plugging it into a P2P (which are the green and purple circular ports that your and keyboard go into) for mouse to get power, it would require a restart. I suggest using a USB mouse because it a plug n go.