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If this just started after you replaced the toner cartridge, one would have to say that it is a bad toner cartridge. Print something that smudges. Pull down the front cover and look at the cartridges. Pay attention to the top one(black). Look at the drum on that cartridge. You should see the toner sitting there. Compare it to the other cartridges which should be clean.
Try reducing the print resolution using the menu buttons. Does it smudge with coloured prints? If so then the fuser unit is faulty. If it is only black that smudges it is likely to be the K Developer unit. Ensure that you are using genuine toners, not refills or third party as the quality of toner can cause similar results.
Try performing a test by printing a test page from Tray 1 and open the top cover as soon as the paper is 60% inside. The paper would jam below the toner cartridge before it reaches the fuser. Remove the toner cartridge carefully and verify if the smudges occur. This would eliminate the fuser. If the print quality is fine, then you need to swap the fuser.
- Try to reallign the cartridge, run a print test, after that if the issue still persist - uninstall and reinstall software - run test and re-allign again the cardtridge using software. run print test again.
Are you sure this is a Designjet 450 (large format printer) and not a Deskjet 450 (portable printer)? The following assumes you have wispy black streaking on the printed side of the paper. If the streaking is on the back side then post more details of the printer model and the issue.
In either case the most likely cause is a buildup of fibers on the underside of the printheads or carriage, causing wisps of black ink to be dragged on the paper when the carriage reverses direction. You can clean the printer as shown at the following (though the details will be somewhat different for the Designjet or Deskjet....).
If you're still getting smudges, there must still be a label or part of a label either on one of the image drums or the transfer belt, i've found in the past it somethings gets stuck inside the unit on the cleaning blade. What i suggest is you run a print and open the front door at the paper travels along the transfer belt, look at all the image drums and see if you can see the smudge on one of them, if so the problem is caused by that cartridge if not it's in the transfer belt somewhere. You may need to try stopping the printer a few times and if the problem is in one of the cartridges, you will mst likely have to replace it, as with the transfer belt if you think that's causing the problem it's easier to remove it and rotate the belt manually.
Please note the image drums and the transfer belt are all light sensative
Can only be two things the drum or the fuser. More than likely drum they last about 4 toners i think.
Learn the art of getting a page to stop halfway threw printing, you want to stop the page after the drum has put a image on the paper but before paper has gone threw the fuser (hotbit).
Once you have mastered the position correctly by stopping the printing by opening the door and removing drum/toner cartridge, to reveal the paper that is printed but can be rubbed off, we will know if marks are coming from the drum (you will see them) or from the fuser, if print is fine.