Did you restart or reboot your system? if not restart your system and see whether it's working or not. Most of the time replacing a hardware we need to restart or re-boot the system.
If your mouse doesn't work than use Keyboard.
Press Ctrl+Esc simultaneously than use the arrow key up>choose the control panel>press enter>use right arrow key to choose the mouse option there press enter key again after you have selected.>Using Tab key and arrow key for choosing the option for "setting" that you wanted to change.
See whether the setting is correct or not. If not set your setting.
All the Best!
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Sigh. What mouse (brand, connector type, what mouse before, what mouse after, reason for replacement, does the old mouse still work), what type of computer (brand, mainboard) , what OS, what does not work. Without this information given, nobody will be able to help you.
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