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Well the best thing to do is to start testing your hardware, you could have a problem with your hard drive, or your ram, or your video card, or your usb ports or cable's. You can make diagnostic cd's easily by using these free downloadable utilities: http://www.memtest86.com/download.html This utility is a classic and works great for testing the ram in your computer.
http://mikelab.kiev.ua/index_en.php?page=PROGRAMS/vmt_en This is a video card testing bootable image. If those pass, you can disable the usb ports on your computer from your bios potentially, and or crack open your computer and disconnect them if they are connected to the motherboard with cables :)
You could try using another USB port on your computer. Perhaps that USB port you have the IOmega external harddrive plugged into is bad.
More than likely not, though.
The problem is usually inside the IOmega's case. (External enclosure)
Inside that IOmega external harddrive's case is a regular harddrive as used in a desktop, or laptop computer. To explain;
Harddrives are physically rated in width, as well as type, and size. A laptop harddrive is 2.5 inches across in width. (2 and a half inches) A desktop harddrive is 3.5 inches.
The larger desktop harddrives are usually used in external harddrives that are 500GB, and larger. (Not always the case when it comes to the 500GB size)
Harddrives have two technologies, or types. IDE (PATA) or SATA.
You didn't state the Model Number so I can't even hazard a guess at this point.
The harddrive inside the case plugs into an Interface. The Interface may be separate, and connected via a cable to a small circuit board, or the Interface may be soldered directly to the small circuit board.
It is this Interface, and circuit board which go bad. The solution is to remove the harddrive inside, purchase an inexpensive external enclosure, and install the harddrive into it.
The external enclosure has a USB cable just like the IOmega external harddrive did.
As stated the harddrive inside is just a normal harddrive. Made by a harddrive manufacturer. Could be a Western Digital, or Seagate, or Hitachi, or Maxtor, or Fujitsu, or IBM, just to name a few. (Seagate bought out Maxtor)
On the harddrive will be a decal with it's specifications. You will also be able to physically measure the width.
This external hookup will support harddrives that are 2.5, or 3.5 inches in width, (And 5.25), plus will support both IDE (PATA) or SATA harddrives,
I'm not expert but try freeze therapy. I did it in on mine and it did not work but I hear it does rarely. Basically all you do is wrap the harddrive in a plastic bag tightly to prevent any form of moister entering, leave it in for about two days and plug it back it. It's said that sometimes if the lense is shaken out of place the cold would make the metal go back to original placing. This means you plug the harddrive in while still frozen, just something try before throwing it away or replacing it.
DO NOT buy a Seagatefreeagent drive under any condition if it comes as a gift return it or re-gift to some one you don't like. Like so many others my 500GB external drive just quit working. Has only been plugged in about 6 times and then back into a cabinet to keep safe. In 10 years between 2 workstations 3 laptops and 4 external drives. The only drives that have ever gone bad are the Seagates and newer Maxators. I still have 4 Western digital drives that still work and get used in an external case for back up. They have never failed. Seagate should be responsible for data time and mental anguish.