Either CPU usage reaches 100% to perform a disk operation or to read the Interrupt.
Check the Event Viewer for Specific Errors. You can verify it using the Task or Process Manager. A Sudden increase of the CPU usage.
Typically servers are configured to allocate the CPU for the Background Services. So it can happen. You should not change it.
The other things is your Mouse interrupts (IRQs) are not compatible with another Device such as a Network card you have. (Most probably a network card)
That is a common issue.
You have to check the compatibility of your Devices.
Other Scenarios:
Scan the System for Spyware.
Clean the mouse connectors.
Try booting into safe mode, getting into device manager, deleting the mouse drivers and rebooting will solve the issue as well.
Hope this will help. You can check the IRQs on the web. Please feel free to ask for further help.
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