My computer freezes up (by 2 users)

My computer freezes up once it has booted and while the window washer tries to come on, also the spyware screen comes up. The window washer screen says a problem has occurred with it and I need to reinstall it. But the keyboard will not respond at this point and I can not close the spyware box that has come up behind the window washer alert box. I can't close the window washer box. At that point nothing is going on because I cannot get the mouse to move or any buttons that I push either. I have tried escape, delete,, I have tried alt, control, delete. No response until I depress the power button and shut the computer down.