Cannot Boot!! Not dtect HDD correctly, Please Poer Off, and check H/W .... this i sthe message that appears on my Tascam2488mkII everytime I boot it up... can someone please help

Power up the unit while holding down these five buttons simutainiously ;
shift - shutdown - home - enter - exit
Hold down for about 45 seconds to a minute until you see the stereo light go on. The stereo light 'should' go on. Your screen will be all white, (or blank). The unit will look normal for a minute except your screen will be totally blank. Now, use the shutdown key as if you were shutting down. It will blink when it's ready - power off. Turn unit back on. It should start normally. Your work will be gone, but if you have back-up discs, you can reload it.

I had the exact same thing. my problem was a result of
food caught & sticking switches in the to the down position
especially the TAP button. got it cheep. still use it!

It sounds like you have either a hard drive failure or have lost the internal operating system in your unit.

BE VERY careful if you have critical data as it still might be recoverable.

I would contact the factory on this one.