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Open Device Manager and look at the properties of the device and all USB Root Hub entries. Under the Power Management tab, deselect the check-box for "Allow the computer to turn off this device to save power".
Don't let the computer go into Sleep mode under Power Management.
Also, I would think a serial device might draw a lot of power, getting pretty close to the 500 ma limit imposed on USB ports. The device might be more dependable if connected to a powered USB hub, which might not have this limitation.
Remove and reinstall all USB controllers
To remove and reinstall all USB controllers, follow these steps:
Click Start, click Run, type sysdm.cpl in the Open box, and then click OK.
Click the Hardware tab.
Click the Device Manager button.
Expand Universal Serial Bus controllers.
Right-click every device under the Universal Serial Bus controllers node, and then click Uninstall to remove them one at a time.
Restart the computer, and then reinstall the USB controllers.
Plug in the removable USB storage device, and then test to make
1. The USB to Serial has a comm port number, you can change that in Control Panel>Hardware and Software >Device Manager>Click on the adapter and make sure it's not disabled and try COMM 3 or a diffrent port you might have two conflicting each other.
I use Allen-Bradley and I also have to run it as admistrative privleges.
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There is a good chance the weak spot is your serial to usb adapter. The signals are not compatible so the adapter has a chip and serial driver to convert the signals. If the adapter is not fast enough to convert the signals, you get an error. Here is some more info on adapters. 5 Steps for Selecting the Right USB to Serial adapter